ახალი პუბლიკაცია

ჟურნალში Clinical Neurophysiology (2014 Impact Factor: 3,097) გამოქვეყნდა სამეცნიერო ნაშრომი ფოკალური ეეგ მახასიათებლების თავისებურებები იუვენილური მიოკლონური – და აბსანს ეპილეფსიების დროს (Japaridze G, Kasradze S, Lomidze G, Zhizhiashvili L, Kvernadze D, Geladze K, et al. Focal EEG features and therapeutic response in patients with juvenile absence and myoclonic epilepsy. Clinical Neurophysiology. 2016 Feb;127(2):1182–7). ნაშრომი შესრულებულია “ნევროლოგიისა და ნეიროფსიქოლოგიის ინსტიტუტის” სამეცნიერო-კვლევით ბაზაზე.

Focal EEG features and therapeutic response in patients with juvenile
absence and myoclonic epilepsy

Giorgi Japaridze a, Sofia Kasradze a, Giorgi Lomidze a, Lali Zhizhiashvili a, David Kvernadze a,
Kakha Geladze a, Sándor Beniczky b,c

a Institute of Neurology and Neuropsychology, Tbilisi, Georgia
b Danish Epilepsy Centre, Department of Clinical Neurophysiology, Dianalund, Denmark
c Aarhus University, Department of Clinical Neurophysiology, Aarhus, Denmark

A b s t r a c t

Objective: To investigate the characteristics of focal EEG features in patients with juvenile absence epilepsy
(JAE) and juvenile myoclonic epilepsy (JME), and to assess their possible influence on therapeutic
response.

Methods: Focal EEG features were prospectively scored in 168 consecutive patients. Ninety-six patients
were drug-naïve and 72 patients were already on antiepileptic drugs (AEDs): 38 on adequate medication
and 34 on inadequate medication. Therapeutic response was assessed one year after starting adequate
therapy.

Results: One-hundred-eighteen patients (70.2%) had focal EEG features: 89 patients (53%) had focal
epileptiform discharges, and 80 patients (47.6%) had focal slowing. Most often, these were multifocal
and localized in frontal and temporal regions. Among patients already on AEDs, patients with focal
EEG features were more often treated with inadequate medication due to misdiagnosis, than patients
without focal features. Data on therapeutic response were available for 118 patients; most of them
(90.7%) were seizure free. None of the focal EEG features affected therapeutic response.

Conclusion: Focal EEG features are common in patients with JME and JAE, but they do not influence the
therapeutic response.

Significance: It is important that physicians are aware of the focal EEG features in order to avoid misdiagnosis
and inadequate therapy.